A study of clinical and Hemocytological profile of pancytopenia

Dr. Anil Kumar Gupta; Dr. Vijay Kumar; Dr. M.H.Khan

Volume : VIII, Issue : II, February - 2019

A study of clinical and Hemocytological profile of pancytopenia

Dr. Anil Kumar Gupta, Dr. Vijay Kumar, Dr. M. H. Khan

Abstract :

This is prospective study on clinical and hemocytological profile of pancytopenia studied in Department of Medicine,VIMS/PAWAPURI, NALANDA, BIHAR.100 patients of age more than 14 year presenting with pancytopenia were evaluated.A combined evaluation of physical findings, haematological investigations and bone marrow aspiration were done in all patients. In 100 cases male accounted for 64% and female 36% with M:F ratio 1.7:1.The commonest presenting complaint was generalized weakness and fever,commonest physical finding was pallor followed by splenomegaly and hepatomegaly. The commonest cause of pancytopenia was kala–azar(41%) followed by megaloblastic anemia(37%),subleukemic leukemia(10%),malaria(04%),drug induced(03%),disseminated TB(02%),multiple myeloma (02%) and MDS (2%). In the present study of 100 cases,34 cases had normocytic normochromic anaemia,32 cases had dimorphic anaemia,macrocytic anaemia was found in 24 cases,normocytic hypochromic constituted rest 10 cases. Lowest haemoglobin percentage 1.8gm/dl,lowest ANC 200 cells/mm3 and lowest platelet count 10,000 cells/mm3 were noted in different cases of megaloblastic anaemia. Bone marrow aspiration showed overall hypercellularity in 95 cases and megaloblastic erythroid hyperplasia in 41 cases. The commonest cause of hypercellularity was kala–azar(43%) followed by megaloblastic anaemia(37%),leukemia(10%) and malaria(04%).