A STUDY OF EARLY PREGNANCY VITAMIN D STATUS AND RISK OF PREECLAMPSIA

DR. ARGHYA MAITRA; DR. PRIYADARSHI KUNDU; DR. SABYASACHI PUJARI; DR. MATIUR HOQUE

Volume : VIII, Issue : XII, December - 2019

A STUDY OF EARLY PREGNANCY VITAMIN D STATUS AND RISK OF PREECLAMPSIA

Dr. Arghya Maitra, Dr. Priyadarshi Kundu, Dr. Sabyasachi Pujari, Dr. Matiur Hoque

Abstract :

AIMS & OBJECTIVE: To examine the association between maternal serum 25–hydroxyvitamin D (25[OH]D) concentration in early pregnancy and the subsequent diagnosis of preeclampsia. MATERIALS & METHODS: A prospective Cohort study conducted in the Department of Obstetrics and Gynaecology, Calcutta National Medical College, Kolkata, over 100 women attending regular antenatal OPD during the period MARCH 2018 to AUGUST 2019. After inclusion in the present study , blood samples of all the mothers (n=100) were taken to analyze serum levels of Vit–D at 11–14 weeks of gestational age. They were then followed up upto the end of third trimester (term). RESULTS: In the present study maximum number of patient belonged to 21 – 30 years of age. Association of age vs. preeclampsia was statistically significant (p=0. 0.0007). 78 (78.0%) patients had Vitamin–D deficiency, 14 (14.0%) patients had insufficient Vitamin–D and 8 (8.0%) patients had normal Vitamin–D. In preeclampsia, 4 (66.7%) patients had Vitamin–D Deficiency and 2(33.3%) patient had Insufficient Vitamin–D. Association of Vitamin–D vs. preeclampsia was statistically significant (p=0.0435). CONCLUSION: Vitamin D deficiency may be an independent risk factor for preeclampsia. Preeclampsia was developed in early age group. Vitamin D supplementation in early pregnancy should be explored for preventing preeclampsia.