A Study of High Sensitivity C - reactive protein in ischemic Stroke

Dr. Aswini Kumar Sahoo; Dr. M.Karuna Sagar; Dr.Prasanna Kumar Sannapu; Dr. K.S.Rohini; Dr.V.Sushanth; Dr.B.Venkatesh; Dr. S.C.Mohapatra

Volume : VII, Issue : III, March - 2018

A Study of High Sensitivity C - reactive protein in ischemic Stroke

Dr. Aswini Kumar Sahoo, Dr. M. Karuna Sagar, Dr. Prasanna Kumar Sannapu, Dr. K. S. Rohini, Dr. V. Sushanth, Dr. B. Venkatesh, Dr. S. C. Mohapatra

Abstract :

Aim: To investigate the association of high hsCRP (> 3 mg/L) levels with ischemic stroke and its subtypes in Indian patients.

Study design: Randomized control trial.

Place and duration of study: General Medicine Department, Maharaja’s Institute of Medical Sciences, Nellimarla, Vizianagaram, Vizianagaram Dist, India from October 2014 to September 2016.

Methodology: 60 patients ischemic stroke were selected who were admitted in to ICU and Medical wards, Maharaja’s Institute of Medical Sciences, Nellimarla, Vizianagaram from October 2014 to September 2016. This study is a duration based, done over a period of 24 months with 60 patients who attended the hospital on admission and diagnosed on the basis of CT/MRI in Department of Medicine in Maharajah‘s Institute of Medical Sciences and evaluated with general and systemic examination and Laboratory studies including estimation of hs–CRP value. Controls were healthy subjects chosen from patients with no present or past history of stroke, transient ischemic attack (TIA), or cardiac disease.

Results: Most of the patients (53.3%) were in the age group of 60 – 70 years. Left–sided hemiparesis with altered sensorium with facial palsy was the most common presenting symptom. hsCRP levels were found to be increased in stroke patients and on comparison with controls, the values were found to be significant (p < 0.001). Also, the values were found to be more in haemorrhagic than ischaemic stroke. No significant correlation was seen with other risk factors like diabetes, dyslipidaemia. It was also seen that patient with low GCS score had high levels of hsCRP in both types of stroke. Mean hsCRP level was 14.8 ± 6.2 in non–survivors of haemorrhagic and 10.7 ± 5.4 in ischaemic stroke. These values were found to be statistically significant (p < 0.001).

Conclusion: : From this study we concluded that hsCRP level is increased in cases of stroke – ischaemic as well as haemorrhagic, suggesting an inflammatory response in acute stroke. Furthermore, the increased levels correlated with larger infarct and bleed, severe neurological deficit and worse outcome.