A STUDY OF HISTOLOGICAL CHANGES OF PLACENTA IN NORMOTENSIVE AND TOXAEMIA OF PREGNANCY WOMEN.

MIRZA R U BEG; T. PRAVEEN

Volume : VIII, Issue : V, May - 2019

A STUDY OF HISTOLOGICAL CHANGES OF PLACENTA IN NORMOTENSIVE AND TOXAEMIA OF PREGNANCY WOMEN.

Mirza R U Beg, T. Praveen

Abstract :

The placenta is a unique organ where maternal and foetal tissues come in direct contact without rejection, suggesting immunological acceptance of the foetal graft by the mother. The placenta is the most accurate record of infant’s prenatal experiences. Structural and functional derangement of placenta evokes a considerable interest, as this may be the only yardsticks to measure adequacy of the foetal environment. Toxaemia of pregnancy is an important reason for large number of maternal deaths and there of foetal deaths. Maternal hypertension (Toxaemia of pregnancy) is diagnosed in 6–10% of all deliveries which is associated with 22% of perinatal foetal deaths and 30% of maternal death. The present study was done in 220 pregnant mothers, divided into four groups. 120 cases of Normotensive pregnant woman(control), 40 cases of pregnant woman with mild preeclamptic, 40 cases of pregnant woman with severe preeclampsia, 40 cases of pregnant woman with Eclampsia pregnant women admitted in the department of Obs and Gynae, Rama Medical College, Hospital and Research Centre, Mandhana, Kanpur, U.P(India).Histological parameters placentae such as syncytial knots, vasculosyncytial memane, Cytotrophoblastic Proliferation and Tunica Media Proliferation of foetal blood vessels measured by standard procedures. It was observed histological parameters of placenta syncytial knots, Cytotrophoblastic Proliferation and Tunica Media Proliferation of foetal blood vessels measured were increased significantly in eclampsia, severe and mild preeclampsia group when compared with control group placenta whereas vasculosyncytial memane of placenta reduced significantly. Abnormal histological changes of placenta in Toxaemia of pregnancy affects placenta adversely and leads significant gross changes as compared to control group, it was contributed by the insufficient blood supply to placenta due to preeclampsia. This study results provides useful adjunct in planning and management of future pregnancy in pregnancy induced hypertensive women