A STUDY ON CLINICO-EPIDEMIOLOGICAL PROFILE OF BREAST CARCINOMA IN EASTERN UTTAR PRADESH

Rashmi Chaturvedi; Anshita Arora

Volume : VIII, Issue : II, February - 2019

A STUDY ON CLINICO-EPIDEMIOLOGICAL PROFILE OF BREAST CARCINOMA IN EASTERN UTTAR PRADESH

Rashmi Chaturvedi, Anshita Arora

Abstract :

Introduction: Breast cancer is the most common female cancer worldwide representing nearly a quarter of all cancers. Public health measures require an understanding of pattern of disease and its clinical presentation. Therefore the current research was conducted to study clinico–epidemiological profile of reported east carcinoma cases. Methods: Sample consisted of 155 specimens of east carcinoma received by Pathology department (retrospectively and prospectively), Hind Institute of Medical Sciences, Barabanki, Uttar Pradesh from June 2015 to May 2018. ER, PR and AR positive expression were defined as ≥10% nuclear staining and also HER2 (2+), FISH was performed. Nuclear staining was done for estimation of Ki–67. Results: Among the study population, most of the east carcinoma cases (67.1%) belong to 35–60 years age group. About 54.2% of the cases were from post–menopausal group. Left side of the east carcinoma (54.5%) was more common. In about 20% of the east carcinoma cases lymph nodes were involved. Lympho–vascular embolization was detected in 13.5% cases. Majority of cases had high Ki–67 grade (40.0%), absence of ER expression (77.4%), absence of PR expression (78.0%) and absence of HER2/neu expression (80.0%) respectively. Conclusion: Breast carcinoma in India shows a quite different spectrum of presentation and behaviour both in early as well as advanced stage.