A study on histopathological Grading of Colorectal Carcinoma in a tertiary centre

Dr. Saravanan.B.; Dr. P.S.Vamitha

Volume : IX, Issue : II, February - 2020

A study on histopathological Grading of Colorectal Carcinoma in a tertiary centre

Dr. Saravanan. B. , Dr. P. S. Vamitha

Abstract :

Introduction Colorectal carcinoma is third most common cancer with incidence rate of 10.25 and mortality rate of 9.2%.It is an old age Malignancy, The changing trends with increasing incidence in young age due to life style modification.TNM stage and Nodal metastasis are important prognostic factors. Several studies indicate Grade as a stage independent prognostic factor. So our study aims to study its prognostic significance. Aims To study prognostic significance of the histopathological grade of tumour in correlation with Tumour stage, nodal metastasis and TNM stage. Materials and Methods Retrospective study of surgical resection 26 colorectal carcinoma cases with completed data was included. Data were collected from the Archive. They were studied for Grade, Tumour stage, Nodal metastasis and TNM stage .Statistical significance of the Grade is analyzed in correlation with Tumour, Nodal Metastasis and TNM stage using Chi square test. Results No Statistical significant correlation noted between Tumour stage and histopathological grade. But correlation between grade with Nodal metastasis and overall TNM Stage showed statistical significance with P valve of 0.035946 and 0.017751 respectively. Conclusion Nodal metastasis is a well known Independent prognostic factor in deciding adjuvant chemotherapy and clinical outcome. Our study showed significant correlation between the Histopathological grades with Nodal metastasis, it may also serve as additional prognostic factor.