A STUDY ON PATTERN OF CUTANEOUS MANIFESTATION OF SYSTEMIC LUPUS ERYTHEMATOSUS IN A TERTIARY CARE HOSPITAL OF NORTH INDIA

Dr Shweta Agarwal; Rajeev Agarwal

Volume : VIII, Issue : VIII, August - 2019

A STUDY ON PATTERN OF CUTANEOUS MANIFESTATION OF SYSTEMIC LUPUS ERYTHEMATOSUS IN A TERTIARY CARE HOSPITAL OF NORTH INDIA

Dr Shweta Agarwal, Rajeev Agarwal

Abstract :

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune connective tissue disease with multi–organ involvement with skin being the second most commonly affected organ. SLE with skin lesions can produce considerable morbidity resulting from painful skin lesions, oral ulcers, disfigurement or toxic epidermal necrolysis like manifestations, etc. Skin lesions in patients with lupus may be specific (LE specific) or non–specific (LE non–specific) as per the Gilliam classification of skin lesion associated with Lupus Erythematosus (LE). Patients with acute cutaneous LE (Lupus specific) have high chances of having systemic disease. Objective: This study was planned to evaluate the frequency and pattern of skin manifestations of SLE, in a tertiary care hospital of Lucknow in North India. Material and Methods: This was a retrospective, observational study carried out in a tertiary care centre of North India over a period of 2 years (April 2017 – March 2019). 40 patients of SLE (5 male and 35 female), attending the Dermatology OPD of a tertiary care centre were enrolled in the study. Results: The mean age of patients was 26 years; 87.5% patients were female and 12.5% were male. Out of 40 patients, oral ulcers were seen in 28 (70%), malar rash in 22 (55%), photosensitivity in 21 (52.5%) patients, discoid rash in 15 (37.5%), alopecia in 19 (47.5%), palpable purpura in 10 (25%), nail changes in 10 (25%), erythema multiforme in 7 (17.5%), Raynaud’s phenomenon in 5 (12.5%), subacute cutaneous LE in 3 (07.5%), bullous eruptions in 3 (07.5%), telangiectasia in 2 (05%), facial oedema in 2 (05%), lupus panniculitis in 1 (02.5%), cheilitis in 1 (02.5%), lichen planus in 1 (02.5%). Conclusion: SLE was predominantly seen among young female patients. Oral ulcer was the most common manifestation followed by malar rash and photosensitivity in our study.