A STUDY ON PROGNOSTIC SIGNIFICANCE OF ER AND PR STATUS ALONG WITH Ki67 IN MENINGIOMA

DR. RANJITA KUMARI; DR. RABINDRA KUMAR SINGH; DR. ABHISHEK KUMAR VERMA

Volume : VII, Issue : VII, July - 2018

A STUDY ON PROGNOSTIC SIGNIFICANCE OF ER AND PR STATUS ALONG WITH Ki67 IN MENINGIOMA

Dr. Ranjita Kumari, Dr. Rabindra Kumar Singh, Dr. Abhishek Kumar Verma

Abstract :

Meningioma is the most common CNS tumor in adults, usually attached to the dura. It accounts for approximately 35% of all primary CNS neoplasms. Meningiomasare benign neoplasms and usually demarcated from adjacent ain tissue. There is a marked female predominance in adults. An association between steroid hormone and risk of meningioma has been reported including an increased incidence of tumor in women, growth during pregnancy, presence of progesterone and to a lesser extent estrogen receptor.Aim– To conduct a retrospective study to evaluate the presence of estrogen and progesterone receptors in meningiomas and to correlate their expression to proliferative marker Ki67. Materials and methods– 30 cases of meningioma s were studied immunohistochemically to detect the expression of ER, PR and Ki67. Other parameters like age and sex were also analyzed.