AN UNUSUAL CASE OF PEPTIC ULCER DISEASE CAUSED BY ZOLLINGER ELLISON SYNDROME

Volume : VII, Issue : V, May - 2018

Bhupender Kumar, Dalip Gupta, Satish Kumar, Ranjot Kaur

Zollinger Ellison syndrome or gastrinoma is a neuroendocrine tumor which was first reported in 1955 by the two surgeons. NETs

are considered as rare disorder but now the incidence is rising and it is not due to the increase in the disease burden but due to

increased no. of patients being diagnosed. Autopsy studies have reported more than 1000 fold higher incidence. So ZES is also not

as uncommon and now it is being diagnosed more. We need to have a high index of suspicion especially among the patients of

refractory PUD and simple and cheap tests like fasting serum gastrin levels and gastric pH estimation are enough to diagnose ZES.

Early diagnosis can be very crucial as 60%–90% of the gastrinoma tumors can become malignant and there are limited treatment

options for the metastatic disease. Other investigations like endoscopic ultrasonography, CT scan, MRI and SRS are useful for

delineating the tumor and planning definite management.