Analysis of the Correlation between Prostate Specific Antigen and Gleason Grade Group in Patients with Prostate Carcinoma

Vinit Kumar Singh; M Mujeebu Rahiman; Altaf Khan; Nischith D‘Souza

Volume : VIII, Issue : IV, April - 2019

Analysis of the Correlation between Prostate Specific Antigen and Gleason Grade Group in Patients with Prostate Carcinoma

Vinit Kumar Singh, M Mujeebu Rahiman, Altaf Khan, Nischith D 8216 Souza

Abstract :

Prostate cancer (PCa) is the one of the most common cause of cancer death among men globally. Prostate–specific antigen (PSA) has been widely used as a screening for PCa. The aim of the study is to evaluate the correlation of serum PSA and Gleason grade group in diagnosis of PCa. Total 30 male patients with age >55 years with Lower urinary tract symptoms (LUTS) and serum total PSA >4ng/ml has been included in the study. All the patients have undergone transrectal ultrasound (TRUS)–guided prostate biopsy (PBx). The results showed that incidence of prostate cancer in our study was 26.58 % for PSA between 4 to ≤10 ; 41.86% patient were positive for adenocarcinoma in the range of PSA between >10 to ≤20. 88.89 % of patient diagnosed with Prostatic adenocarcinoma with serum total PSA >20. Histopathology report Gleason grade group and total serum PSA correlation was then calculated. Our study suggests that there is a high correlation between PSA and carcinoma differentiation grade determined by Gleason‘s system, as well as low correlation between PSA and tumor differentiation grade. In conclusion, a strong correlation was found between the total PSA level and tumor diagnosis, tumor aggressiveness. In real–life practice with serum total PSA testing, a greater chance of a positive cancer result, high–grade cancer, was found in patients with a higher PSA level.