Antimicrobial, Anthelmentic, Antioxidant and Phytochemical Investigation of Glochidion tomentosum Dalz.an medicinal tree

Jagadeesh K S; Sharanappa P

Volume : VIII, Issue : I, January - 2019

Antimicrobial, Anthelmentic, Antioxidant and Phytochemical Investigation of Glochidion tomentosum Dalz.an medicinal tree

Jagadeesh K S, Sharanappa P

Abstract :

In the present study, we made an effort to screen the bioactive compounds from endangered medicinal tree Glochidion tomentosum Dalz. collected from Western Ghats regions of Karnataka. Preliminary phytochemical analysis of soxhlet extracts in bark of G. tomentosum revealed the presence of tannins, terpenoids, alkaloids, glycosides, steroids and absence of flavonoids and saponins. The carbohydrate content (59.9 %) and nutritive value (cal/100 g) was found to be greater than 300 cal/100 g. Macro nutrients like phosphorus and potassium was found to be higher content. In case of microelements viz., Fe, Mn, Zn and Cu are found to possess high concentration.The result of antibacterial activity of G. tomentosum was determined against the panel of 13 pathogenic bacteria. Among bacteria, more inhibition was recorded in case of Pseudomonas aeruginosa by extracts followed by Escherichia coli and Staphylococcus aureus. P. aeruginosa was inhibited at low concentration (0.35 mg/ml) followed by E.coli (0.40 mg/ml) and S. aureus (0.50 mg/ml) by ethanol extract of G. tomentosum. Minimum inhibitory concentration of G. tomentosum was found to be 0.30, 0.30 and 0.40 mg/ml for E. coli, P. aeruginosa and S. aureus respectively. In case of G. tomentosum the anthelmintic effects were comparable with that of 1% piperazine citrate with higher doses namely 30mg/ml and higher. Overall, anthelmintic potential was higher in ethanol extract than petroleum ether extract. The ethanol extract of G. tomentosum have shown concentration dependent radical scavenging activity. It showed 89.41 % of inhibition at 1 mg/ml concentration. The extracts have shown dose dependent scavenging activity. Ethanol extract showed 82.70±1.560 % of inhibition and petroleum ether extract showed 69.31±1.350 % of inhibition at 60 µg/ml concentrations