ASSESMENT OF MICROVASCULAR COMPLICATIONS IN TYPE 2 DIABETES MELLITUS PATIENTS WITH SPECIAL REFERENCE TO HbA1c AND PLATELET INDICES(MPV)

Pradeep Nigam; Beerbhan Singh; Akash Singh Yadav

Volume : VIII, Issue : X, October - 2019

ASSESMENT OF MICROVASCULAR COMPLICATIONS IN TYPE 2 DIABETES MELLITUS PATIENTS WITH SPECIAL REFERENCE TO HbA1c AND PLATELET INDICES(MPV)

Pradeep Nigam, Beerbhan Singh, Akash Singh Yadav

Abstract :

INTRODUCTION: Diabetes mellitus (DM) is not a single disease entity but rather a group of metabolic disorders shå the common underlying features of hyperglycemia. Platelet volume, a marker of the platelet function and activation, the higher the MPV, the larger and younger the platelets are and more is the risk for thrombosis and are associated with increased risk for hyperglycemic complications.OBJECTIVE:To assess correlation of microvascular complications in T2DM patients with special reference to HbA1c and platelet indices(MPV).MATERIALS AND METHODS: This cross sectional analytical study was carried out in our institution for duration of 1 year.Total of 500 subjects was enrolled in the study.Detailed clinical and demographic profile including duration of diabetes and presence of microvascular complications was noted. The data was analysed using SPSS Version 16.RESULT:MPV is significantly higher in patients with poor glycemic control(HbA1c >7) and presence of microvascular complications compared to patients with good glycemic control (HbA1c≤7) and absence of microvascular complications (p value is <0.05 which is highly significant).CONCLUSION:Our study showed that in poor glycemic control group patients with presence of microvascular complications there is significantly higher MPV values.Hence MPV can be used as a simple and cost effective indicator for the glycemic control and microvascular complications in T2DM patients.