Assessment of Redox Balance in Nephropathy Associated with Type 2 Diabetes mellitus

Mathew John; Misna Mohamed; Sinju R

Volume : VII, Issue : VI, June - 2018

Assessment of Redox Balance in Nephropathy Associated with Type 2 Diabetes mellitus

Mathew John, Misna Mohamed, Sinju R

Abstract :

The study was assessing the role of oxidative stress in diabetic nephropathic group in comparison with diabetic group without any secondary complications. We observed that there was a significant imbalance in redox status in nephropathic diabetic group when compared to diabetic group without metabolic problems. This was evident from our result which showed that there was depletion in glutathione status in diabetic nephropathy along with reduction in activity of glutathione peroxidase as well as catalase. However, we also observed that the superoxide dismutase activity was elevated in diabetic nephropathic group in comparison with diabetic control. This could be attributed to increased generation of superoxide anion in nephropathy where SOD activity removes excess superoxide anion which is deleterious. The other finding was there was significant elevation of thiobarbituric acid reactive substances in diabetic nephropathy which was a compounding factor for severe oxidative stress in diabetic complications associated with nephropathy.