Assessment of the level of homocysteine and its correlation with the degree of severity of CAD by coronary angiography

Ajay Sharma; Abhinav Nair; Rohit Shrivastava; Bhoopendra Bhadauriya

Volume : VII, Issue : III, March - 2018

Assessment of the level of homocysteine and its correlation with the degree of severity of CAD by coronary angiography

Ajay Sharma, Abhinav Nair, Rohit Shrivastava, Bhoopendra Bhadauriya

Abstract :

Cardiovascular diseases which comprise of diseases of the heart and the blood vessels, are believed to account for about 1/3^rd of all the deaths worldwide with the prevalence still on a steep rise. There are multiple contributory factors to this disease, thus making it difficult to pin–point a single factor responsible. Homocysteine has been recognized as a risk factor as early as 1990s, for the presence of atherosclerotic vascular disease and hypercoagulability states. There has been a long standing debate regarding to the extent to which homocysteine should be considered as a risk factor for CAD, and as such many authors doubt this association. Hence this study was planned to assess the levels of homocysteine in patients presenting with a clinical diagnosis of CAD and then correlating it with the degree of severity of CAD by coronary angiography. The summary was a statistically significant higher levels of mean plasma homocysteine in patients with TVD compared to DVD and SVD, thus establishing that severity of angiographically detected CAD is positively associated with the persons total homocysteine levels.