ASSOCIATION BETWEEN BACTERIAL INFECTION AND SEVERITY OF ATOPIC DERMATITIS

Carolus Trianda Samosir; Rita Evalina; Lily Irsa; Mahrani Lubis

Volume : VII, Issue : V, May - 2018

ASSOCIATION BETWEEN BACTERIAL INFECTION AND SEVERITY OF ATOPIC DERMATITIS

Carolus Trianda Samosir, Rita Evalina, Lily Irsa, Mahrani Lubis

Abstract :

Atopic dermatitis (AD) is a chronic inflammatory andresiding skin disease. Several factors are known to promote bacterial colonization in AD skin, such as altered epidermal barrier, increased bacterial adhesion, defective bacterial clearance, and decreased innate immune responses. Compared to normal individuals, people with AD exhibit higher skin bacterial density. It is found that infection in AD skin associates with the increased severity of inflammation, which was shown by the SCORAD index. Incidence of skin infection was also found higher in more severe AD. Clinical manifestations, especially severity and intensity of lesion, showed association with the incidence of infection, suggesting its role as predicting factors and potentially serve as a basis in giving antibacterial treatment in AD.