Association of Cytochrome P450 mono-oxygenase and Neutrophil MPO (Myeloperoxidase) Activity in Diabetes and non-diabetic foot ulcer patients

Dr.Prasanta Kumar Bhattacharyya; Priyanka Biswas; Dr.Debarshi Jana; Dr.Jayanta Ranjan Mukherjee; Dr.Madhusanta De

Volume : VIII, Issue : III, March - 2019

Association of Cytochrome P450 mono-oxygenase and Neutrophil MPO (Myeloperoxidase) Activity in Diabetes and non-diabetic foot ulcer patients

Dr. Prasanta Kumar Bhattacharyya, Priyanka Biswas, Dr. Debarshi Jana, Dr. Jayanta Ranjan Mukherjee, Dr. Madhusanta De

Abstract :

Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of the diabetic foot. The aim of the study to find any association of Diabetic foot ulcer with Cytochrome P450 mono–oxygenase and Neutrophil MPO(Myeloperoxides) Activity We found that activation of Cytochrome p450 Mono Oxygenase level was significantly lower in Type2 DM with Foot Ulcer than Healthy Control (t=8.5553). T–test showed that mean Cytochrome p450 Mono Oxygenase of Type2 DM with Foot Ulcer patients had significantly lower than others. Over expression of Neutrophil Myeloperoxidase level was significantly higher in Type2 DM with Foot Ulcer than Healthy Control (t=57.7285). T–test showed that mean Neutrophil Myeloperoxidase of Type2 DM with Foot Ulcer patients had significantly higher than others. Adverse Foot Ulcer events associated with Type II diabetes may be in part a result of enhanced Cytochrome p450 Mono Oxygenase expression and activity.