Association of Psoriasis Severity Hypothalamic Pituitary Adrenal Axis Function

Dr Sunjanaa Dhepa R L; Dr Srivenkateswaran K; Dr. Sivasubramanian V

Volume : IX, Issue : VI, June - 2020

Association of Psoriasis Severity Hypothalamic Pituitary Adrenal Axis Function

Dr Sunjanaa Dhepa R L, Dr Srivenkateswaran K, Dr. Sivasubramanian V

Abstract :

OBJECTIVE: Evaluation of role of cortisol and Adrenocorticotrophic hormone , a key component of the hypothalamic pituitary adrenal axis , in influencing the severity of psoriasis METHODOLOGY: Prospective study was conducted involving 100 subjects for a duration of 1 year. Serum Adrenocorticotrophic hormone and cortisol was evaluated for all participants and the correlation with psoriasis severity was elicited. RESULTS: Among the study subjects it was found that the mean comparison of cortisol was significantly lower (P value < 0.001) whereas in Adrenocorticotrophic hormone it was significantly higher(P value <0.001). A significant positive correlation was seen between PASI and Adrenocorticotrophic hormone whereas a significant negative correlation was seen between PASI and cortisol levels. CONCLUSION: The daily stressors cause HPA axis dysfunction due to which the levels of Adrenocorticotrophic hormone is increased and the levels of Cortisol is decreased which relatively increases the severity of psoriasis.