C-Reactive Protein as a reliable prognostic marker in patients with perforative peritonitis : a prospective study

Dr. Manivannan Velayutham; Dr. Rajeswari Mani

Volume : IX, Issue : II, February - 2020

C-Reactive Protein as a reliable prognostic marker in patients with perforative peritonitis : a prospective study

Dr. Manivannan Velayutham, Dr. Rajeswari Mani

Abstract :

The aims of the study were to find whether an increase in C–reactive protein was a reliable prognostic marker in patients with perforative peritonitis and to determine whether the levels of C–reactive protein had any correlation with the type of perforation.A total of 104 patients with perforative peritonitis presented to Madras Medical College,Rajiv Gandhi Government General Hospital from Feuary 2018 to November 2018 were chosen and allocated into two groups based on the outcome as mortality or survival.88 patients were in the survival group and 16 patients were in the mortality group.the C–reactive protein distribution in both these groups were recorded along with the type of perforation.Data were processed using SPSS software.All values were expressed as mean±standard deviation / median.Comparison of C–reactive protein between the two groups was done using student’t’test and prognostic accuracy of the parameters were done using ROC curve analysis.It was found that an increase in C–reactive protein was associated with adverse outcome in perforative peritonitis patients.From this study,we conclude that C–reactive protein is a reliable marker of survival.It allows timely identification of high risk patients and can be used as a marker for risk stratification and hence can be considered a reliable prognostic marker in perforative peritonitis.It can also be concluded that there is no correlation between C–reactive protein and type of perforation.