CALCIUM GLUCONATE CO-ADMINISTERED WITH NEOSTIGMINE FASTEN NEUROMUSCULAR BLOCKADE RECOVERY IN PEDIATRIC PATIENTS: A DOUBLE- BLIND RANDOMIZED CONTROLLED PILOT STUDY

GUNJAN SINGH; SOUVIK MAITRA; PUNEET KHANNA; AJAY SINGH; RUMA THAKURIA; LOKESH KASHYAP; RAVINDER BATRA

Volume : VIII, Issue : IV, April - 2019

CALCIUM GLUCONATE CO-ADMINISTERED WITH NEOSTIGMINE FASTEN NEUROMUSCULAR BLOCKADE RECOVERY IN PEDIATRIC PATIENTS: A DOUBLE- BLIND RANDOMIZED CONTROLLED PILOT STUDY

Gunjan Singh, Souvik Maitra, Puneet Khanna, Ajay Singh, Ruma Thakuria, Lokesh Kashyap, Ravinder Batra

Abstract :

Background : Reversal agents given after completion of surgery have variations in neuromuscular recovery time. Few studies are published regarding the role of using calcium with reversal agents for faster recovery in adults only but not in pediatric group. Aim : Compare the duration of neuromuscular recovery after giving reversal drug with or without calcium gluconate in pediatric patients. Primary outcome was assessment of neuromuscular recovery time. Secondary outcome, train of four was measured at the end of surgery at 3, 5 and 10 minutes after giving reversal Results: Neuromuscular recovery time, Train of four ratio (TOFr) 5 min after neostigmine administration was significantly decreased in calcium group. Residual neuromuscular blockade 3 min after giving reversal was significantly higher in control group. Conclusion: In the calcium group, time for reversal administration to extubation as well as to end of anaesthesia was significantly shorter than in the control grou