Can Cleome Viscosa protect against Diabetic Sciatic Neuropathy in Albino Rats? A Histological Study

Mohamed E.A. Mostafa; Abdullah H. Altemani; Ashraf M. F. Kamel

Volume : VII, Issue : I, January - 2018

Can Cleome Viscosa protect against Diabetic Sciatic Neuropathy in Albino Rats? A Histological Study

Mohamed E. A. Mostafa, Abdullah H. Altemani, Ashraf M. F. Kamel

Abstract :

Background: The possible protective role of Cleome Viscosa (Cl V) in experimental peripheral neuropathy was investigated in diabetic (streptozotocin [STZ] induced) Albino rats.

Material and Methods: Forty adult male albino rats were divided into four groups; control, sham control, experimental group that received STZ and a protection group that received Cl V 4 weeks before STZ. Sciatic nerve specimens were subjected to light and electron microscopy as well as morphometric analysis.

Results: The sciatic nerve in diabetic rats showed axonal shrinkage, axon–myelin separation, onion–bulb, vacuolization of the myelin sheath with formation of fermentation chambers, thickening of the epineurium, as well as sub–epineurial edema. Administration of Cl V prior to induction of diabetes was associated with decreased DPN histopathological abnormalities.