Volume : III, Issue : VI, June - 2014

Abstract :

Haemoglobin D (Hb D) is the fourth most common haemoglobin variant. With the exact chemical analysis of hemoglobin variants, it became apparent that hemoglobin DLos Angeles was identical to hemoglobin DPunjab, both manifesting a substitution of glutamate for lysine at the 121st position in the β –chain. Another “D” hemoglobin, GPhiladelphia, is, on the other hand, an β–chain variant with a substitution of asparagine for lysine at the 68th position. Like the other structural mutations of hemoglobin, hemoglobin D trait is the heterozygous state for hemoglobin D and hemoglobin A, whereas the homozygous state for hemoglobin D is designated hemoglobin D disease. Hb D disease is usually clinically silent with no special treatment required. Homozygous Hb DD is rare and a relatively mild disease. Though Hemoglobin D is not very uncommon in India, its homozygous form is very rare and very few case reports have been reported. I hereby present a case of symptomatic Hb D homozygous, who presented with hemolytic anemia and hepatospleenomegaly from Turvekere, Karnataka which is a rare phenomenon.

Article: Download PDF    DOI : https://www.doi.org/10.36106/paripex  

Cite This Article:

, PARIPEX-INDIAN JOURNAL OF RESEARCH : Volume-2 | Issue-3 | March-2013

Number of Downloads : 135

References :