Co-relation of serum Prostatic Specific antigen and histopathological findings of prostatic lesion.

Volume : VII, Issue : IV, April - 2018

Dr C V Kulkarni, Dr Aksharaditya Shukla, Dr Ashok Yadav

Introduction: Prostatitis, benign nodular hyperplasia of prostate and carcinoma prostate are the common diseases associated

with prostate. Prostate cancer is the most common cancer of men in USA and 10th common malignancy in India. PSA is

synthesized by normal lining epithelial cells of prostatic glands, cells of hyperplastic glands and malignant epithelial cells of

prostatic adenocarcinoma. So there may be increase in serum PSA level in conditions like inflammation, hyperplasia and

malignancy. As in most of the cases with PSA less than 04 ng/dl there is very less chances of malignancy and in serum PSA level

more than 10 ng/dl possibility of carcinoma prostate is highly suggested.

Material and Methods: This study is conducted in department of Pathology, MGM Medical College Indore. Patients whose

serum PSA was available and histopathological examination was requested were included. Histopathological examinations was

done and findings were co–related clinical and laboratory findings. Serum PSA level and histopathological co–relation was

recorded and analyzed.

Results and observation: Most patients were of 61– 70 years of age group. Benign lesions were more common, constituting

83% of the cases, they included prostatic hyperplasia Prostatitis and other lesions. Serum PSA level was found maximum in cases

of malignancy (ranging from 06.10 ng/dl to 144 ng/dl). In inflammation of prostate there is rise in sPSA titre which should always

be examined cautiously. Mean serum PSA in malignant cases was found to be 39.38 ng/dl. In prostatic carcinoma most of the

patients show Gleason score of 7–8. Most common Gleeson grade was grade 4 in our study.

Conclusion: Prostatism is a very common cause of morbidity among elderly males. Serum PSA levels are important and very useful

diagnostic tool in assessment of prostatic lesions. Raised serum PSA should always alarm a clinician and pathologist to examine

patient with suspicion. Rise in PSA level is directly proportional to the grade of tumor. Thus histopathological examination and corelation

of serum PSA level with Gleeson grading are most crucial parameters in deciding treatment line of patient.