COMPARATIVE EFFICACY OF BEPOTASTINE BESILATE 1.5% VS OLOPATADINE HYDROCHLORIDE 0.2% OPHTHALMIC SOLUTION IN THE IMMEDIATE RELIEF OF SYMPTOMS OF ALLERGIC CONJUNCTIVITIS

Thangerani Raajaseharan; Nazeem Farzana Ghouse

Volume : VIII, Issue : I, January - 2019

COMPARATIVE EFFICACY OF BEPOTASTINE BESILATE 1.5% VS OLOPATADINE HYDROCHLORIDE 0.2% OPHTHALMIC SOLUTION IN THE IMMEDIATE RELIEF OF SYMPTOMS OF ALLERGIC CONJUNCTIVITIS

Thangerani Raajaseharan, Nazeem Farzana Ghouse

Abstract :

Ocular and nasal discomfort associated with allergic conjunctivitis is a common complaint in an ophthalmic OPD. Allergic conjunctivitis is a Type I hypersensitivity reaction triggered by repeated antigen exposure. After sensitization, contact with the allergen causes mast cell degranulation and histamine release. Targeting this are the dual action agents having anti–histaminic and mast– cell stabilizing properties – Bepotastine besilate 1.5% and Olopatadine hydrochloride 0.2% ophthalmic solution. A study population of 100 patients between 21 – 50 years with symptoms of allergic conjunctivitis after getting an informed consent were randomly instilled with one drop of the drug and assessed for immediate relief within 5min. Our study found that Bepotastine Besilate 1.5% showed a superior efficacy in the immediate relief of symptoms within 3 min. Thus proving that this non– steroidal drug can be used as an initial therapy for immediate relief of symptoms of allergic conjunctivitis