Volume : VII, Issue : VII, July - 2018

COMPARATIVE EVALUATION OF ADDITION OF CLONIDINE VS NORMAL SALINE TO THE PHARMACODYNAMICS AND PHARMACOKINETICS OF INTRATHECALLY ADMINISTERED HYPERBARIC BUPIVACAINE FOR SPINAL ANAESTHESIA IN LOWER LIMB ORTHOPAEDIC SURGERIES

Dr. Anuradha Swaminathan

Abstract :

 INTRODUCTION: This study was undertaken to assess the behaviour of intrathecal clonidine as an adjuvant to bupivacaine in

augmenting sensory block in patients undergoing lower limb surgeries.
MATERIALS AND METHODS: Patients were randomly divided into two groups of 30 each. Group N: 16.25 mg of 0.5%
hyperbaric bupivacaine + 0.25 ml of normal saline, Group C: 16.25 mg of 0.5% hyperbaric bupivacaine + 0.25 ml(37.5mcg) of
clonidine. Onset and duration of sensory block and motor block, the highest level of sensory blockade, duration of analgesia and
side effects were assessed.
RESULTS: The onset of motor block was faster in group C when compared to group N. The time to reach Bromage scale 3 was
fastest in group C. The duration of sensory, motor blockade and duration of analgesia was longer in group C than group N. The
time to regression time to S1 was longer in group C. Duration of analgesia was significantly prolonged in group C.
CONCLUSION: Supplementation of bupivacaine spinal block with low dose of intrathecal clonidine(37.5mcg) produces a
significantly shorter onset of motor and sensory block and a significantly longer sensory and motor block than bupivacaine with
normal saline

Keywords :

Article: Download PDF    DOI : https://www.doi.org/10.36106/paripex  

Cite This Article:

Dr.Anuradha Swaminathan, COMPARATIVE EVALUATION OF ADDITION OF CLONIDINE VS NORMAL SALINE TO THE PHARMACODYNAMICS AND PHARMACOKINETICS OF INTRATHECALLY ADMINISTERED HYPERBARIC BUPIVACAINE FOR SPINAL ANAESTHESIA IN LOWER LIMB ORTHOPAEDIC SURGERIES, PARIPEX‾INDIAN JOURNAL OF RESEARCH : Volume-7 | Issue-7 | July-2018


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