Comparative study between epidural nalbuphine and epidural butorphanol for post-operative analgesia in total abdominal hysterectomy.

Dr. Amol Jadhavar; Dr. Jyoti Kale

Volume : IX, Issue : VIII, August - 2020

Comparative study between epidural nalbuphine and epidural butorphanol for post-operative analgesia in total abdominal hysterectomy.

Dr. Amol Jadhavar, Dr. Jyoti Kale

Abstract :

Introduction–Epidural opioids acting through spinal cord receptors improves the quality and duration of analgesia along with dose spå effect with the local anaesthetics. The present study was designed to evaluate the efficacy and safety profile of epidurally administered butorphanol and nalbuphine combined with bupivacaine. MATERIAL AND METHODS– 80 patients of age group 30–60 years belonging to ASA Ι and ΙΙ posted for total abdominal hysterectomy were randomized into two groups B and N of 40 each. Combined spinal epidural technique was adopted for all patients. Spinal anaesthesia was given with 4 ml of 0.5% heavy bupivacaine. In post–operative period the study drug was given through epidural catheter. Group B received Inj. butorphanol 2 mg and group N received Inj. nalbuphine 10 mg with 0.25% 6 ml bupivacaine. Duration and quality of analgesia, hemodynamic changes and side effects such as sedation, pruritus, PONV, respiratory depression and urinary retention were recorded and compared. RESULTS– The demographic data were comparable in two groups. Duration of analgesia was 185.63±17.22 mins and 159±14.33 mins in group B and N respectively and difference was found to be statistically extremely significant (p value<0.0001). Sedation scores and urinary retention were significantly higher in B group than N group. No other side effects were observed. CONCLUSION– Both butorphanol and nalbuphine were effective for relieving postoperative pain, however quality and duration of analgesia was more with butorphanol. However butorphanol causes more sedation and urinary retention than nalbuphine.