Comparative Study Comparing Cyclosporine VS Tacrolimus Five year follow- up In Ahmed GRTC At Khartoum State (December 2000- March 2006)

Volume : VII, Issue : V, May - 2018

Nada Abd Elrahman Mohammed, Ragaa Edward Samaan, Nahid Osman Ahmed, Mona Mohammed Yahia, Maha Mukhtar Haj Abdu, Dr. Sanya Shadad

Background: Kidney transplantation is the treatment of choice for most patients with end–stage renal disease (ESRD). This study

was undertaken to compare the efficacy of Tacrolimus with the micro– emulsion formulation of Cyclosporine in population

under going renal transplantation. A five year, retrospective comparative study was conducted at AHMED GASIM RENAL

TRANSPLANTATION CENTER (AGRTC).

Methods :178 renal transplant recipients were studied retrospectively, using data recorded from (AGRTC) to evaluate efficacy of

calcineurin inhibitors (Tacrolimus vs Cyclosporin A Microemulsion). Calcineurin inhibitors were used in combination with both

Azathioprine and steroids. Follow–up data were collected at five year post–transplantation from 81 (45.5% of the study

population) patients who received Tacrolimus and 97(54.5%of the study population) patients who received. Whereas whole

blood level targets were 1020 , 515 and 5–7 ng/ml for Tacrolimus and 100400 ,100200 and 125–150 ng/ml for CsA during

months 03 ,46 and 7 –12 to 60 respectively.

Results:The study found no difference between cyclosporine and Tacrolimus in the composite primary efficacy endpoint,

including biopsy–proven acute rejections, graft loss In the Tacrolimus treatment group, totaling 13 (16.1%). Cyclosporine

totaling 20 (20.61%). and patient survival Calculated on whole populations, overall mortality (5.6% vs 10.6%; P.>0.05) was

grater, but overall rate of graft loss (7.3% vs 10.7%; P = 0.938 in analysis) was not significantly different after 5 years with

tacrolimus– vs cyclosporine–based immunosuppression. Thus, there was no significant loss or death difference. In the Tacrolimus

arm, [10 (12.3% deaths]. In the cyclosporine group, [19 (19.5%) deaths].

Conclusions : The one five year follow–up results confirm that Tacrolimus is as efficacious as cyclosporine immunosuppressant in

kidney transplantation.