Comparative study of intravenous labetalol versus Oral Nifedipine in Hypertensive Disorders of Pregnancy in a tertiary care hospital

Subhashree Priyadarshini; Pratima Mishra; Ruchita Richa

Volume : IX, Issue : I, January - 2020

Comparative study of intravenous labetalol versus Oral Nifedipine in Hypertensive Disorders of Pregnancy in a tertiary care hospital

Subhashree Priyadarshini, Pratima Mishra, Ruchita Richa

Abstract :

Objective: To compare intravenous Labetalol and oral Nifedipine in terms of rapidity to control BP, no. of doses required, maternal and fetal outcome in hypertensive disorders of pregnancy . Methods:–All pregnant women with BP more than 150/100mmHg were randomized to receive IV labetalol ( in escalating dose i,e 20,40,80,80,80 mg) and oral Nifedipine(10mg) until the target BP of 140/90 mmHg was achieved . Results:– Mean time required in labetalol group was 43.5±15.7mins and Nifedipine was 44.7±15.7 mins with P >0.05. There was significant fall in DBP with labetalol than nifedipine within 15mins. Maternal heart rate increased in nifedipine group and decreased in labetalol group. No patients required cross over treatment. Conclusion:– Both drugs are equally effective and safe in controlling BP in hypertensive disorders of pregnancy but labetalol stood better to decrease DBP and no. of patients responding to 1st dose than Nifedipine