COMPARATIVE STUDY OF ISOFURANE AND HALOTHANE ON BIS INDEX AT EQUAL END-TIDAL MINIMUM ALVEOLAR CONCENTRATION IN SPINE SURGERY.

Dr. Tarun Lall; Dr. P.S. Lamba

Volume : VII, Issue : VI, June - 2018

COMPARATIVE STUDY OF ISOFURANE AND HALOTHANE ON BIS INDEX AT EQUAL END-TIDAL MINIMUM ALVEOLAR CONCENTRATION IN SPINE SURGERY.

Dr. Tarun Lall, Dr. P. S. Lamba

Abstract :

Introduction

Awareness can be defined as the subjective experience of external or internal stimuli. BIS index remains the most validated form of consciousness of ain function monitoring used within the clinical context of anesthesia and sedation care.

Material & Methods

The study was conducted in SMS Medical College and attached hospital, Jaipur after approval from the institutional ethical committee.Hospital based, double blinded, randomized comparative study.Sample size was calculated to be 16 subjects in each of the two groups at α (alpha) error 0.05 in power 80% assuming detectable difference in mean BIS values of Isoflurane and halothane to be 5.4 and 5.2. Hence for study purpose 25 subjects will be taken in each of the two groups.

Results

The mean BIS value for isoflurane group at 0.5 MAC was 55.44±1.873 as compared to mean BIS value 66.04±1.541 for halothane group. (P value= 0.000 S). Similarly, we seen significant difference in mean BIS value for isoflurane and halothane at 1 MAC and 1.5 MAC (wash–in phase). During wash out phase mean BIS value for isoflurane and halothane At 1 MAC and at 0.5 MAC have significant difference.

Conclusion

At equal – MAC end tidal concentration isoflurane produces less BIS values than halothane. The BIS values for volatile anesthetics may be agent specific. No significant effect on hemodynamic, HR and blood pressure with isoflurane and halothane both.