Comparison between hypolipidemic effect of Lagenaria siceraria and Lovastatin in hypercholesterolemic rats

Pushpendra Kumar; Aafreen; Suraj Kumar; Mudit Kumar

Volume : VIII, Issue : II, February - 2019

Comparison between hypolipidemic effect of Lagenaria siceraria and Lovastatin in hypercholesterolemic rats

Pushpendra Kumar, Aafreen, Suraj Kumar, Mudit Kumar

Abstract :

Hyperlipidemia is acknowledged to be a major risk factor for atherosclerosis and cardiovascular diseases. The purpose of the study is to compare between the hypolipidemic effect of Lagenaria siceraria and Lovastatin in hypercholesterolemic rats. Hyperlipidemic rats were randomized into two groups (5 in each). Oral administration of the aqueous extract of Lagenaria siceraria (200 mg/kg b.wt/day) to Group I and Lovastatin (7.2 mg/kg b.wt/day) to Group II, once in a day for two weeks was done. Both the group has shown significant reduction in total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and very low density lipoprotein (VLDL), but Group II has shown higher reduction. Thus, the study concludes that besides the standard drug lovastatin, Lagenaria siceraria can also serve as a drug for treating hyperlipidemia