COMPARISON OF INCIDENCE OF CONGENITAL- ANOMALIES IN DIFFERENT IVF-PROCEDURES

Dr Monica Singh; Dr Randhir Singh

Volume : VIII, Issue : VIII, August - 2019

COMPARISON OF INCIDENCE OF CONGENITAL- ANOMALIES IN DIFFERENT IVF-PROCEDURES

Dr Monica Singh, Dr Randhir Singh

Abstract :

Background: A retrospective cohort study was conducted to evaluate and compare the incidence of congenital anomalies in babies and fetuses conceived after four procedures of assisted reproduction techniques (ART)– IVF, ICSI, IVF–FET and ICSI–FET. Material and Methods The prevalence of congenital anomalies was compared retrospectively between ALL ART babies and fetuses conceived via all procedures of IVF–ICSI (ART) – in vitro fertilization with standard insemination (IVF), IVF with Intracytoplasmic sperm injection (ICSI), IVF with frozen emyo transfer (FET– IVF), and ICSI with frozen emyo transfer (FET–ICSI). Congenital anomalies were described according to European Surveillance of Congenital Anomalies (EUROCAT) classification. The parental backgrounds, biologic parameters, obstetric parameters, and perinatal outcomes were compared between babies and fetuses with and without congenital anomalies. Data were analyzed by the generalized estimating equation. Results: All IVF–ICSI–FET (ART) evolutionary pregnancies were included in the analysis. Our present study showed 04% babies and fetuses had a congenital anomaly . The major incidence found among the recorded anomalies were congenital heart defects, chromosomal anomalies, and urinary defects. However, the risk of congenital anomalies in babies and fetuses conceived after FET was not increased compared with babies and fetuses conceived after fresh emyo transfer, even when adjusted for confounding factors. Conclusion: There is no increased risk of congenital anomalies in babies and fetuses conceived by fresh versus frozen emyo transfer after in vitro fertilization with and without micromanipulation. Indeed, distribution of congenital anomalies found in our study population is consistent with the high prevalence of congenital heart defects, chromosomal anomalies, and urinary defects that have been found by other authorsalso in children conceived by infertile couples when compared to children conceived spontaneously.