COMPARISON OF PRE AND POST PLATELETPHERESIS VALUES OF HEMOGLOBIN, HEMATOCRIT AND PLATELET COUNT IN HEALTHY DONORS.

Mitali Sharma; Vijay Sawhney; Ankur Malhotra

Volume : VII, Issue : XI, November - 2018

COMPARISON OF PRE AND POST PLATELETPHERESIS VALUES OF HEMOGLOBIN, HEMATOCRIT AND PLATELET COUNT IN HEALTHY DONORS.

Mitali Sharma, Vijay Sawhney, Ankur Malhotra

Abstract :

INTRODUCTION: Now a days, the cell separators can yield high dose plateletpheresis, resulting in up to four units of apheresis platelets for transfusion to patients. However, concerns regarding the safety of platelet donors run contrary to these interests and technical possibilities. This can be easily investigated by measuring the Hb , Hct and total platelet counts, of normal donors before and after plateletpheresis. As these hematological changes may induce clinical implications to the donor such as anaemia and thrombocytopenia.

AIM: To compare the pre and post plateletpheresis values of Haemoglobin , Haematocrit and platelet count in healthy voluntary donors.

MATERIAL AND METHOD: The study was conducted on 57 healthy, plateletpheresis donors over a period of one year. The plateletpheresis procedures were performed using COM.TEC,FRESENIUS Kabi apheresis machine with closed system apheresis kit various pre– and post–donation haematological values such as haemoglobin concentration (Hb), haematocrit (Hct)and platelet counts, were measured in all donors.

RESULTS: We observed that the Hb, Hct,and platelet counts decreased significantly in the donors (p<0.01) after each procedure.

CONCLUSION: Although a significant drop in Hb, HCT and platelet count was observed in all donors, none manifested features of anaemia and /or thrombocytopenia. Changes were within normal range and did not lead to any significant adverse effects on the donor. In conclusion, it can be said that, plateletpheresis is a safe procedure for healthy donors