Correlation between Insulin Resistance and pattern of dyslipidaemia in Psoriasis.

Dr. Suparna Dhara; Dr. Indrajit Nath; Dr. Anindya Dasgupta

Volume : VII, Issue : III, March - 2018

Correlation between Insulin Resistance and pattern of dyslipidaemia in Psoriasis.

Dr. Suparna Dhara, Dr. Indrajit Nath, Dr. Anindya Dasgupta

Abstract :

Objectives: The present study was aimed to assess the relationship between the pattern of dyslipidaemia and body fat deposition with insulin resistance in Psoriatic patients.

Material &methods: Body mass index (BMI) and waist circumference(WC) were measured in 40 psoriaitic patients against matched controls. Fasting Blood Glucose (FBG) and Triglyceride(TG),Cholesterol(CHOL), Low density lipoprotein(LDL), Very low density lipoprotein(VLDL), and High density lipoprotein(HDL) were measured by spectrophotometry. Insulin resistance was assessed by measuring the HOMA–IR values.

Results: FBG, WC and HDL between this two groups were statistically not significant (p value=0.271, 0.21 and 0.72 respectively). On the other hand, BMI, HOMA–IR, TG, CHOL, LDL and VLDL levels were significantly higher in the case group (p < 0.05). Bivariate correlation analysis showed HOMA IR to be significantly associated with FBG, BMI, WC, Total CHOL and LDL (but not with VLDL, TG and HDL values.

Conclusion: mainly an increased insulin resistance that is directly related to significantly elevated levels of abdominal obesity and LDL cholesterol levels reflects metabolic derangements in psoriatic patients in this region. We suggest regular monitoring of psoriatic patients for these parameters to avoid the impending cardiovascular risks in them.