CORRELATION OF APOPTOTIC INDEX WITH HISTOLOGICAL GRADING IN BREAST CARCINOMA PATEINTS

DR NATASHA MAKKAR; DR VIRANDER PAL SINGH

Volume : VII, Issue : VI, June - 2018

CORRELATION OF APOPTOTIC INDEX WITH HISTOLOGICAL GRADING IN BREAST CARCINOMA PATEINTS

Dr Natasha Makkar, Dr Virander Pal Singh

Abstract :

Background: Carcinoma east is globally the most common cancer in women and second most common cause of cancer death worldwide. Apoptotic index– a measure of the rate of death of cancer cells within a tumour, is an independent prognostic marker. Apoptotic index is usually low in benign east lesions. It graduallyincreases with increasing grade and is highest in invasive carcinoma.Methods: In all mastectomy cases, histological findings were noted along with assessment of grade and apoptotic index. The mean apoptotic index was compared with the grades. Results: Grade II infiltrating ductal carcinoma was seen in most of the cases. Grade III tumours had a significantly higher mean apoptotic index (p–value =0.000). Conclusion: Apoptotic index gradually increases with increasing grade in east cancer.