DAPSONE HYPERSENSITIVITY SYNDROME IN A PATIENT WITH HANSENS‘S DISEASE

N. Akshita; Likhitha Marni; Dr G. Ramya Bala Prabha; Sharadha Srikanth; Konde Abbulu

Volume : VIII, Issue : IV, April - 2019

DAPSONE HYPERSENSITIVITY SYNDROME IN A PATIENT WITH HANSENS‘S DISEASE

N. Akshita, Likhitha Marni, Dr G. Ramya Bala Prabha, Sharadha Srikanth, Konde Abbulu

Abstract :

Introduction: Adverse drug reactions (ADRs) are one of the leading causes of death in hospitalized patients. ADR is a response to a drug which is noxious, unintended and occurs at doses normally used in human for prophylaxis and treatment. Dapsone, a potent antiparasitic and anti–inflammatory compound, is mainly used in the treatment of leprosy and a variety of blistering skin diseases. It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome. We report a case of dapsone hypersensitivity, manifesting as fever, rash, and hepatosplenomegaly, hemolytic anemia. Discussion: A forty six old male, known case of Hansen’s disease for the last 1 month. He had been on Dapsone for 1 month as the prescribed by dermatologist for Hansen’s disease. Later the patient developed red rash all over the body, red skin lesions, fever with chills, epistaxis, nasal stuffiness, multiple nodules on body, hepatosplenomegaly, photophobia and watery eye. A Clinical diagnosis of Dapsone induced hypersensitivity syndrome was made Dapsone was stopped immediately. During the hospital administration, patient was managed symptomatically for fever, skin rash, and systemic corticosteroids were given as standard treatment.He was discharged with special warnings and also advised to continue MB–MDT treatment without dapsone. Conclusion: By the withdrawal of the drug, the condition of the patient was improved. So the drug withdrawal is the first line for management of Dapsone induced hypersensitivity syndrome.