Volume : VII, Issue : VII, July - 2018

Diabetic Foot Ulcer : a study in a Tertiary Hospital in Puduchery (South India)

Dr. C. Meenakshisundaram, Dr. G. Jayalakshmi, Dr. P. Selvaraj

Abstract :

A total of 40 patients (30 males, and 10 females) were taking treatment for diabetic foot infections in a tertiary hospital situated in a peri–urban locality  inPuduchery(South India),  during a period of 9–months from October 2015 to July 2016. The data on bacterial culture and antibiotic sensitivity patterns wereanalysed for evaluating the effectiveness of various antimicrobial agents in offering treatment to diabetic foot ulcer patients.

In total, 67 bacterial organisms were isolated, amounting to 1.675 organisms per patient. The Gram–negative organisms were 56.7%, and Gram–positive organisms were 43.3%. The most predominant among the Gram–positive organismswere Staphylococcus aureus (14.9%),  plus  MRSA (3.0%). The most predominant Gram–negative organisms were Pseudomonas species (10.4%) plus Pseudomonas aeruginosa (6.0%).The Enterobacteriaceae species were 40.3%, including the   ESBL–producing Escherichia coli (3.0%). 

Patients infected with one pathogen were 45.0 % (18/40). Another 42.5 % (17/40) were infected with two pathogens. The remaining 12.5 % (5/40) of patients were infected with three pathogens. Nobody had more than 3 pathogens.The ages of patientsvaried from 36 to 84, showing 55.0% of infection in patients above 50 years of age.

The 9–months’  data revealed that Amikacin  was the most effective drug against  all Gram–negative pathogens, and a few Gram–positive organisms excepting  Enterococcus and Streptococcus species (to which Penicillin, or Ampicillin was effective). Vancomycin and Linezolid  were effective, in cases wherever they were tested against Gram–positive organisms. Clindamycin was effective against Gram–positive organisms, excepting in the case of MRSA and Beta–hemolytic Streptococcus strains. Imipenem was spåly used against Gram–negative organisms.Gentamicin or Ciprofloxacin or Cephalosporins  were effective only in a few (limited) cases of infections involving  Gram–negative organisms.

Conclusion : Continuous monitoring of bacterial antibiotic  sensitivity is recommended for strengthening the baseline data at the local centre, aimed at  enhancing a better treatment  approach for diabetic foot ulcer.

Article: Download PDF    DOI : https://www.doi.org/10.36106/paripex  

Cite This Article:

Dr. C.Meenakshisundaram, Dr.G.Jayalakshmi, Dr. P.Selvaraj, Diabetic Foot Ulcer : a study in a Tertiary Hospital in Puduchery (South India), PARIPEX‾INDIAN JOURNAL OF RESEARCH : Volume-7 | Issue-7 | July-2018


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