EFFECT OF 5-ALPHA REDUCTASE INHIBITOR ON THE VASCULARITY OF BPH AFTER TURP

Dr Prabhat Kumar; Dr S.K. Sinha; Dr D. K. Das; Dr Shweta Kumari; Dr Chandrahas Yadav

Volume : VIII, Issue : XII, December - 2019

EFFECT OF 5-ALPHA REDUCTASE INHIBITOR ON THE VASCULARITY OF BPH AFTER TURP

Dr Prabhat Kumar, Dr S. K. Sinha, Dr D. K. Das, Dr Shweta Kumari, Dr Chandrahas Yadav

Abstract :

OBJECTIVE: To assess the effects of 5–α–reductase inhibitor (finasteride) on vascularity of prostate in patients with BPH undergoing TURP by measuring preoperative and postoperative Hb by comparison with control cases. METHODOLOGY: A total of 78 patients of Benign Prostatic Hyperplasia (BPH) planned for Trans–Urethral Resection of Prostate (TURP) having a prostate size of more than 50 grams on trans–abdominal ultrasonography andor transrectal ultrasonography with PSA of less than 0.4 ngdl was divided into 2 groups, each group having 39 patients. The finasteride group (Group A) was prescribed oral 5 mg of finasteride daily for 2 weeks before surgery. The Group B (Group B) did not receive any agent. After 2 weeks, TURP was performed and variables were recorded. RESULTS: There was no significant difference in the mean age of patients, prostate volume, PSA and preoperative hemoglobin level in both groups. There was significant reduction in mean blood loss, blood loss/time, and total blood loss per gram of resected tissue in finasteride groups compared with the other group. Besides these, amount of irrigation fluid used and duration of irrigation was more in the Group B. CONCLUSION: The 5–α–reductase inhibitors (finasteride) reduces intraoperative and postoperative blood loss in patients with BPH undergoing TURP if given two weeks before surgery as well as decrease rate of blood transfusion, amount of irrigation fluid used and duration of irrigation needed to clear hematuria postoperatively.