EFFECT OF INTRAVENOUS LORNOXICAM ON THE HAEMODYNAMIC RESPONSE FOLLOWING LARYNGOSCOPY AND INTUBATION

Dr Nimish Danial; Dr Jiju Yeldho

Volume : VII, Issue : V, May - 2018

EFFECT OF INTRAVENOUS LORNOXICAM ON THE HAEMODYNAMIC RESPONSE FOLLOWING LARYNGOSCOPY AND INTUBATION

Dr Nimish Danial, Dr Jiju Yeldho

Abstract :

Aim:

To determine the hemodynamic effects of intravenous lornoxicam and its effect on stress response to laryngoscopy and endotracheal intubation.

Methods:

In this double – blind randomized placebo–controlled study,50 patients about to undergo general anaesthesia with endotracheal intubation were randomly allocated into two groups. Group 1– Lornoxicam group, where 25 patients received intravenous lornoxicam 16 mg 30 minutes before laryngoscopy and intubation after test dose and Group 2– Control group, where 25 patients received placebo (normal saline) intravenously 30mts before laryngoscopy and intubation.

Systolic and diastolic BP, mean arterial pressure and heart rate changes were recorded before and after administration of general anaesthesia at 1, 3, 5 and 10 minutes post–intubation in both groups.

Results were analysed statistically using student’s t test to determine the p value and significance of the observations.

Results:

Post laryngoscopy and intubation, there was a definite reduction in the peak values of systolic BP, diastolic BP, mean arterial pressure and heart rate in lornoxicam group and the difference was significant at 1mt and 3mt in case of systolic BP; 1mt, 3mt, 5mt, 10mt in case of diastolic BP; 3mt, 5mt and 10mt in case of mean arterial pressure and 1mt, 3mt, 5mt and 10mt in case of heart rate when compared to the control group.

Conclusion:

Pretreatment with16mg intravenous lornoxicam is effective in attenuating the cardiovascular stress response to laryngoscopy and tracheal intubation.