EFFECT OF THYROID HORMONE ON HbA1c LEVELS IN PATIENTS WITH NEWLY DETECTED HYPOTHYROIDISM

Dr Raghunandan Meena; Dr Subhita Choudhary; Dr Khushala Ram Choudhary

Volume : IX, Issue : I, January - 2020

EFFECT OF THYROID HORMONE ON HbA1c LEVELS IN PATIENTS WITH NEWLY DETECTED HYPOTHYROIDISM

Dr Raghunandan Meena, Dr Subhita Choudhary, Dr Khushala Ram Choudhary

Abstract :

Introduction: HbA1c is an important parameter in diagnosis of diabetes. However, Glycated hemoglobin (HbA1c) may not accurately reflect the level of glycemia in conditions of altered erythrocyte turnover. Objective: to determine HbA1c levels in non–diabetic patients with newly detected hypothyroidism and to determine the effect of thyroid hormone replacement therapy on HbA1c levels. Material and method: A prospective study was carried out July 2019 to December 2019 in the Department of Medicine in a tertiary care teaching institute in Jhalawar, District, Rajasthan. Total 128 Patients with newly detected hypothyroidism were included in this study. Thyroid hormone replacement was prescribed for 3 months to all patients.Paired t–test (2–tailed) was used to compare means of different parameters before and after the restoration of euthyroid state. Results: Thyroid replacement therapy showed a statistically significant difference in haemoglobin level (p=0.008), thyroid profile (p=0.001) and HbA1c level (p=0.007) of study participants. There was a significant negative correlation between glycosylated haemoglobin and serum T4 levels (r =–0.42, p <0.05). Serum TSH level shows significantly positive correlation with glycosylated haemoglobin (r = 0.26, p <0.05). Conclusion: The study revealed a statistically significant reduction in mean HbA1c after thyroid replacement therapy which concludes that correction of hypothyroid states was associated with fall in HbA1c levels. A significantly positive correlation was found between Serum TSH level and glycosylated hemoglobin. It implies that that thyroid hormone affects HbA1c values.