Effect of Topical Platelet Rich Plasma on Burn Healing After Partial Thickness Burn Injury

Nora Minori; Utama Abdi Tarigan; Frank Bietra Buchari

Volume : VIII, Issue : VII, July - 2019

Effect of Topical Platelet Rich Plasma on Burn Healing After Partial Thickness Burn Injury

Nora Minori, Utama Abdi Tarigan, Frank Bietra Buchari

Abstract :

PRP application helps heal the wound and fastens reepithelialization in wound area. Platelets play an important role in hemostasis and wound healing after tissue damage. After trauma, platelets will activate fiinogen and form fiin clot that works as hemostatic agents and tissue adhesive. PRP increases collagen type I expression, MMP–1 and mRNA in human’s fioblast. PRP induces the synthesis of new collagen through fioblasts. By adding PRP or PPP in cell culture will help fat stem cells and human’s dermal fioblasts proliferation. Materials and Method: Forty Wistar albino rats were divided into 3 groups of 10 rats each. Group 1 (platelet–rich plasma group) was exposed to burn injury and topical platelet–rich plasma was applied. Group 2 (control group) was exposed to burn injury only. Group 3 (blood donor group) was used as blood donors for platelet–rich plasma. The skin tissue was harvested on the fourteenth day and the rats were killed on the same day. Tissue’s fioblast, PMNL, vessels proliferation and collagen were examined histologically. Result: Histopathologically, there were significantly higher fioblast, vessels proliferation and collagen levels (P>0.05) in the platelet–rich plasma group than in the control group. There is no significant difference in PMNL in both group statistically. Conclusion: Platelet–rich plasma seems to improve burn healing in this experimental burn injury model. As an initial conclusion, it appears that platelet–rich plasma can be used in humans, although further studies should be performed with this type of treatment.