Effective Steps Towards the Application of Silver Nanoparticles as Safe Systemic Infection Controlling Agents

Prasanta Kumar Maiti; Rehana Parveen; Paramita Ghosh

Volume : IX, Issue : I, January - 2020

Effective Steps Towards the Application of Silver Nanoparticles as Safe Systemic Infection Controlling Agents

Prasanta Kumar Maiti, Rehana Parveen, Paramita Ghosh

Abstract :

Silver nanoparticles (AgNPs) possess potent pan–microbicidal properties with non–specific synergisms for different antimicrobial agents, yet none found suitable for systemic use for potential risk of host cell damage. AgNPs prepared from silver nitrate using dextrose as reducing and human serum as mixture of stabilizing agents, also show all antimicrobial properties. There is least possibility of internalization by receptor–ligand attachment in human cells and liberation of any toxic components after de–capping for bio–mimicking outer coat. For their antimicrobial actions against different multi–drug resistant pathogens at any point of cell cycle and wide range nonspecific synergism with different antibiotics, can be used at safe low dosage with or without synergistic antibiotics. In–vitro study on human liver cell–line (WRL–68) and in–vivo study in mice model indicated wide margin of safety. Thus, major life–threatening infections caused by super–bugs can be managed in future by such safe systemic useable Nano–antimicrobials