Emerging fluoroquinolone resistance in ocular pathogens.

Dr.Ashok Kumar Meena; Dr.Pushpendra Chotiya; Dr.Jaishree Singh

Volume : VII, Issue : III, March - 2018

Emerging fluoroquinolone resistance in ocular pathogens.

Dr. Ashok Kumar Meena, Dr. Pushpendra Chotiya, Dr. Jaishree Singh

Abstract :

Introduction: The fluoroquinolone cover a host of Gram –negative,Gram–positive microorganisms and anaerobes.Incidence of in vitro resistance to older Fluoroquinolone increasing because of misuse,inappropriate dosing and schedule.

Methodology: Study was done on 100 pateints suspected of bacterial ocular infections.Cultures were performed , sensitivity testing done by disc diffusion method. Grades were recognized sensitive,intermediate,resistant by compå the diameters of inhibition zone according to CLSI guidelines.Eyes were treated by eye drops of older group including ciprofloxacin 0.3%,ofloxacin 0.3%,and newer group including gatifloxacin 0.3%,moxifloxacin0.5%,besifloxacin0.6%.

Conclusion and results:In this prospective study,it was found that resistance against newer fluoroquinolones is less in comparison to older.Bacterial drug resistance can be reduced by proper use of antibiotics,cycling of different antibiotics in chronic cases,culture and sensitivity study in serious infections and use of fluoroquinolones on the basis of susceptibility profiles ,using mutants prevention concentration.