Erythroleukemia: diagnosis and evolution

Marie Ose Judicael HARIOLY NIRINA; Marie Ose Michael HARIOLY NIRINA; Ndrantoniaina RASAMOELINA; Anjaramalala Sitraka RASOLONJATOVO; Aimee Olivat RAKOTO ALSON; Andry Mampionona RIEL; Nasolotsiry Enintsoa RAVELOSON

Volume : VII, Issue : VII, July - 2018

Erythroleukemia: diagnosis and evolution

Marie Ose Judicael Harioly Nirina, Marie Ose Michael Harioly Nirina, Ndrantoniaina Rasamoelina, Anjaramalala Sitraka Rasolonjatovo, Aimee Olivat Rakoto Alson, Andry Mampionona Riel, Nasolotsiry Enintsoa Raveloson

Abstract :

Erythroleukemia or acute erythroblastic leukemia is a proliferation of erythrocyte population compared to other bone marrow lines. We describe in this work a case of erythroleukemia which can be classified in AML with myelodysplasia abnormalities according to the WHO classification 2016 of AML with erythroblastic component.

We report case of a 38 years old patient with no significant history, seen in pre–anesthesia consultation in intensive care unit of Morafeno University Hospital Toamasina Madagascar.

The initial hemogram showed anemia, leucopenia and thrombocytopenia without blood blastosis. The myelogram was in favor of erythroleukemia according to the FAB classification.

Medullary immunophenotyping was positive for MPO, CD13, CD33 and glycophorin A. Molecular study found mutation of FLT3 Internal Tandem Duplication (FLT3–ITD) gene. Cytogenetic study did not find recurrent cytogenetic abnormalities. The development was rapidly unfavorable and the patient died 17 days later of acute respiratory distress.