Estimation of the De Ritis ratio in the cases of chronic alcoholic liver disease attending OPD of a tertiary health care level institute of Kanpur,U.P.

Indra Prasad Adhikari; Dr. R. Tiwari; Dr. Renu Bala

Volume : VII, Issue : I, January - 2018

Estimation of the De Ritis ratio in the cases of chronic alcoholic liver disease attending OPD of a tertiary health care level institute of Kanpur,U.P.

Indra Prasad Adhikari, Dr. R. Tiwari, Dr. Renu Bala

Abstract :

Background: Alcoholic Liver disease (ALD), is a medical illness of alcohol over consumption that includes– fatty liver, alcoholic hepatitis and chronic hepatitis with cirrhosis. The liver cell damage is shown by AST and ALT enzyme in case of ALD. The ratio of the serum activities of AST and ALT was first described by Fernando De Ritis in 1957.So that this ratio is called as De Ritis ratio. The AST/ALT ratio is the ratio between the concentrations of the enzymes aspartate transaminase (AST) and alanine transaminase(ALT) in the blood of a human or animal. It is measured with a blood test and is sometimes useful in medical diagnosis to differentiatebetween causes of liver damage, or hepatotoxicity.Objective– estimation of the De Ritis ratio in the cases of chronic alcoholic liver disease. Materials and Methods: This was a cross–sectional prospective case control study conducted among 100 participants as 50 cases attending OPD of Rama Medical college of Rama University, Kanpur and remaining 50 healthy individuals of same profiles were enrolled as controls in this study. 5 ml fasting venous samples was taken for serum measurement of enzymatic markers of AST and ALT patients and normal healthy individuals and samples were analysed in auto analysers. Results: In the present study the mean age of cases was found 48.06±10.07 yrs and in control group it was found 46.36±9.61yrs. (p = 0.390) and the mean weight of cases was found 64.52± 6.08 kgs and in control group it was found 64.30± 6.03 kgs.( p=0.856) . in present study De Ritis ratio (AST/ALT) in case group it was found 2.03 ± 0.60 and in control group it was found in 1.35 ± 1.20(p = 0.001)Conclusion: In the present study the De Ritis Ratio was found more in the cases of chronic alcoholic liver disease than in non–alcoholics and a significant association was obtained in the enzymatic markers between the alcoholics and non–alcoholics. It can be concluded that the level of De Ritis ratio like (AST/ALP) are raised in alcoholics as compared to non–alcoholics.