Volume : VII, Issue : X, October - 2018

EVALUATION OF ANGIOGENESIS IN EWING SARCOMA

Florin Filip, Roxana Filip, Laurian Lucian Francu

Abstract :

The most human tumours do not produce angiogenesisin the early stages.They can develop for months or years without vascular support, and then perhaps due to the accumulation of mutations, the tumour cells change their phenotype towards angiogenesis.It is thought that this switching would be explained by an increased production of angiogenic factors, and by the loss of angiogenesis inhibitors.All these considerations have directed our research into the qualitative and quantitative assessment of angiogenesis in the Ewing tumour in children.We have studied 42 anatomo–pathologically confirmed bone tumours in children between 3–18 years.We usedimunohystochemical marker antigen associated with factor VIII (von Willeand).Microvascular density was quantified in the area with the most active angiogenesis, using the Weibel parallel gridfrom the PRODIT 5.2. program.In Ewing sarcoma angiogenesis is very intense, the microvascular density reaching the highest values compared to other types of bone tumours. It is similar to grade 4 osteosarcoma and could be interpreted in the same way: poor prognosis through the high risk of metastasis.

Article: Download PDF    DOI : https://www.doi.org/10.36106/paripex  

Cite This Article:

Florin Filip, Roxana Filip, Laurian Lucian Francu, EVALUATION OF ANGIOGENESIS IN EWING SARCOMA, PARIPEX‾INDIAN JOURNAL OF RESEARCH : Volume-7 | Issue-10 | October-2018

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