Evaluation of Anti-cancer potential of Proteinacious Euphorbia tirucalli and Opuntiaficus-indicaCactus extracts : In Vitro Study

Fatma A Helal; Mohamed Galal; Aly Fahmy Mohamed

Volume : VIII, Issue : IX, September - 2019

Evaluation of Anti-cancer potential of Proteinacious Euphorbia tirucalli and Opuntiaficus-indicaCactus extracts : In Vitro Study

Fatma A Helal, Mohamed Galal, Aly Fahmy Mohamed

Abstract :

Proteinacious materials of Euphorbia tirucalli and Opuntia ficus–indica have been utilized widely in society of medicine. This treatise aimed to evaluate the anti–cancer impact of cactus derived extracts on lung squamous cell carcinoma (A549) and colon cell carcinoma (Caco2). Data recorded revealed that a noteworthy inhibitory impact on cells proliferation went with some morphological changes that was cell type and concentration dependent. Likewise, up regulation of both casp–3 and Bax gene went with down regulation of Bcl–2 was identified 24 hrs post cell treatment. Information recorded uncovered that treatment with Euphorbia tirucalli and Opuntia ficus–indica extracts demonstrated clear anticancer potential accompanied with significantly elevated arrested cells during G2–M phase in both cell lines and significant apoptotic cell % induced under the effect of Opuntiaficus–indicaextract (P<0.05) than in case of Euphorbia extract treatment