EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF SIDDHA DRUG VATHANA GHANTHI THYLEM(VGT)USING CARRAGEENAN-INDUCED PAW OEDEMA METHOD IN ALBINO RATS

D.S. Vaniswari; Arunachalam K

Volume : VIII, Issue : VI, June - 2019

EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF SIDDHA DRUG VATHANA GHANTHI THYLEM(VGT)USING CARRAGEENAN-INDUCED PAW OEDEMA METHOD IN ALBINO RATS

D. S. Vaniswari, Arunachalam K

Abstract :

Background:The objective of this study was to assess the anti inflammatory potential of traditional siddha drug Ghanthi Thylem. Materials and Methods: The anti inflammatory of the drug was evaluated using carrageenan– induced paw oedema method. The inflammation was readily produced in the form of edema with the help of irritant such as carrageenan. Albino rats of either sex weighing 180–220g are procured from Central Animal House, J.S.S. College of Pharmacy, Ootacamund,India. Experimental protocol was approved from Institutional Animal Ethical Committee and carried out as per CPCSEA guidelines Results: Both dose of Vathana Ghanthi Thylem(VGT)at a doses of 15 ml/kg and 30ml/kg were tested for their Anti– inflammatory activity by using carrageenan Induced rat paw edema method . Diclofenac sodium 10mg/kg I.P as standard . Discussion: The results reveals that both doses of 15 ml/kg and 30ml/kg Vathana Ghanthi Thylem(VGT) possesses significant Anti inflammatory activity when compared to control group at p<0.01. Conclusion: The results indicate that the traditional drug Ghanthi Thylem was scientifically proven as safe drug for prescribing as medication in prevention of dermatologic problems as mentioned in Siddha text Sikichaarathina deepam,part–I, skin pimples.It act as a preventive medicine that keep individual cosmetic beauty forever