EVALUATION OF BLOOD GLUCOSE CONCENTRATION PROFILE AFTER 8 MG DEXAMETHASONE IN PATIENTS COMING FOR HEAD AND NECK SURGERIES

Aluri Upendra; Habib Rahaman A A

Volume : VII, Issue : III, March - 2018

EVALUATION OF BLOOD GLUCOSE CONCENTRATION PROFILE AFTER 8 MG DEXAMETHASONE IN PATIENTS COMING FOR HEAD AND NECK SURGERIES

Aluri Upendra, Habib Rahaman A A

Abstract :

BACKGROUND AND AIMS: Dexamethasone administration has many advantages in perioperative period. But being a corticosteroid, it can produce detrimental hyperglycaemia which may affect patient adversely. Hence the present study aimed at evaluating magnitude of hyperglycaemia induced by dexamethasone 8mg in patients undergoing elective head and neck surgeries. MATERIAL AND METHODS: 60 patients belonging to ASA physical status I and II of either sex , aged between 18–65 years undergoing elective head and neck surgeries were randomised into two groups of 30 each and received intravenousely. 2 ml bolus of either dexamethasone (8 mg) or normal saline before induction of anaesthesia. Blood glucose measurements were obtained at baseline (T0). Then 60 min (T1), 120 min (T2), 240 min (T3) and 24 hours (T4) after the intravenous injection. Data collected was analysed using Statistical software IBM SPSS 22. RESULTS: There was an increase in blood glucose concentration from baseline at all time periodsinboth the groups. Increase in blood sugar levels was statistically significant in dexamethasone group at T₃ and T₄ compared to normal saline group. CONCLUSION: Perioperative administration of single dose dexamethasone can cause significant increase in blood glucose concentration. Thus, the benefits of administering corticosteroids should be weighed against the potential side effects of hyperglycemia