EVIDENCE OF GENETIC INSTABILITIES AMONG HYPOTHYROID WOMEN WITH BOH

Rahana N; Aswathy Sundaresh; Komala PT; Viji Krishnan; Dinesh Roy D

Volume : IX, Issue : II, February - 2020

EVIDENCE OF GENETIC INSTABILITIES AMONG HYPOTHYROID WOMEN WITH BOH

Rahana N, Aswathy Sundaresh, Komala Pt, Viji Krishnan, Dinesh Roy D

Abstract :

Hypothyroidism is one of the most common endocrine disorders in women of reproductive age. Bad obstetric history (BOH) is the common complication of pregnancy, affecting approximately 15% of all clinically recognized pregnancies. Hypothyroidism in women during pregnancy leads to bad obstetric complications like two or more consecutive miscarriage, placental auption and fetal death. Thus, the present study was undertaken to detect the biochemical & cytogenetic aspects on hypothyroid women with bad obstetric history. The objectives of the present studies are to evaluate the extent of DNA damage and chromosome abnormalities in hypothyroid women experiencing BOH and to assess various demographic, physiological and lifestyle characteristics of hypothyroid women suffering from BOH. The CBMN assay revealed that a statistically significant increase in the mean CBMN frequency among hypothyroid women experiencing BOH. Moreover, there is an association between the extent of DNA damage and various lifestyle and physiological risk factors. The present study proved an increased extent of somatic DNA damages among hypothyroid women experiencing BOH. So maternal hypothyroidism in early gestation is severely affecting the fetal ain development and also has an association between pregnancy complications.