EXPRESSION OF NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) ON BENIGN AND MALIGNANT EPITHELIAL OVARIAN TUMOR TISSUE

Paul Alwin Khoman; Riza Rivany; Yostoto B Kaban

Volume : VIII, Issue : XII, December - 2019

EXPRESSION OF NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) ON BENIGN AND MALIGNANT EPITHELIAL OVARIAN TUMOR TISSUE

Paul Alwin Khoman, Riza Rivany, Yostoto B Kaban

Abstract :

Ovarian tumors are neoplasms derived from ovarian tissue To date, malignant ovarian tumors are treated with adjuvant chemotherapy. Several studies have reported glicoprotein such as Neutrophil gelatinase–associated lipocalin (NGAL) have important roles as a marker for clinical response to chemotherapy and disease prognosis. This is a comparative analytic study using samples from ovarian tissue obtained from April 2018 to September 2018. Data were analyzed by calculating kappa values and relationships between variables using the Chi–square statistical test. P values less than 0.05 were considered significant with 95% CIs. NGAL expression increased significantly in grade I epithelial ovarian tumors (15 patients ;78,9%). The majority of patients with ALLRED score (+) were found in malignant epithelial ovarian tumors (19 patients; 73,1%) and ALLRED score (–) were most common in benign epithelial ovarian tumors.