FLOATING CONTROLLED AND SUSTAINED IN-SITU GELLING SYSTEM: CURRENT APPROACHES

Abhijeet. P. Shirguppe; Amit. M. Belekar; Prashant. S. Salian

Volume : VII, Issue : VIII, August - 2018

FLOATING CONTROLLED AND SUSTAINED IN-SITU GELLING SYSTEM: CURRENT APPROACHES

Abhijeet. P. Shirguppe, Amit. M. Belekar, Prashant. S. Salian

Abstract :

An intensive research have been undertaken to develop drug delivery system to achieve better drug product effectiveness, reliability and safety. In situ forming polymeric delivery systems shows advantages such as ease and reduced frequency of administration, improved patient compliance and comfort.These systems are liquid at room temperature but undergo gelation when come in contact with body fluids or change in pH.The formation of gels depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation. Drug gets released in a sustained and controlled manner from the gel. Various biodegradable polymers are used for the formulation of in situ gels. These are administered by oral, ocular, rectal, vaginal, injectable and intraperitoneal routes. These systems offer sustained and prolonged action in comparison to conventional systems. Also production of such system is less complex and lowers manufacturing cost.